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KMID : 0355620110370050380
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2011 Volume.37 No. 5 p.380 ~ p.385
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Bone regeneration of the fluoridated hydroxyapatite and the bio-glass in the rabbit cranium defect model
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Ahn Hyo-Joon
Han Se-Jin
Kim Kyung-Wook
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Abstract
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Introduction:Hydroxyapatite (Ca10(PO4)6(OH)2, HA) is the main inorganic phase of human hard tissue that is used widely as the repair material for bones. When HA is applied to a bony defect, however, it can be encapsulated with fibrous tissue and float in the implanted area due to a lack of consolidation. Bioceramics as allogenic graft materials are added to HA to improve the rate and bone healing capacity. Fluoridated hydroxyapatite (Ca10(PO4)6(OH,F)2, FHA), where F- partially replaces the OH- in hydroxyapatite, is considered a good alternative material for bone repair owing to its solubility and biocompatibility.
Materials and Methods :This study was designed to determine the bone healing capacity of FHA newly produced as a nanoscale fiber in the laboratory. HA and FHA with bioglass was implanted in a rabbit cranium defect and the specimen was analysed histologically.
Results:1. At 4 weeks, fibrous connective tissue and little bone formation was observed around the materials of the experimental group I implanted HA and bioglass. Newly formed bone was observed around the materials in the experimental group II implanted FHA and bioglass. 2. At 8 weeks, the amount of newly formed and matured bone was higher in experimental group II than in experimental group I and the control group.
Conclusion:These results suggest that FHA and bioglass is a relatively favorable bone substitute with biocompatibility and better bone healing capacity than pure HA and bioglass.
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KEYWORD
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Durapatite, Fluor-hydroxylapatite, Bioglass, Bone Substitutes
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